Indianapolis, IN: Eli Lilly and Company; 2004 Mar 1. From the FDA website. Using quetiapine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use quetiapine, or give you special instructions about the use of food, alcohol, or tobacco. Mainly via hepatic metabolism; less than 1% excreted as unchanged drug. Approximately 73% of dose recovered in urine and 20% in feces. Geddes J, Freemantle N, Harrison P et al. Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis. BMJ. 2000; 321: 1371-6. losartan
The 3 treatment groups were similar in mean change in SAS total score and BARS Global Assessment score at the end of treatment. The use of concomitant anticholinergic medications was infrequent and similar across the three treatment groups. The mean HAM-D total score at entry was 24, and 17% of patients scored 28 or greater. Check with your doctor right away if you have increased thirst or urination. If you have diabetes, the results of your urine or blood sugar tests may change. Check your blood sugar closely and talk with your doctor if you have any questions. If hypotension occurs during titration to the target dose, a return to the previous dose in the titration schedule is appropriate.
Quetiapine Fumarate Extended-Release Tablets was greater than the incidence in placebo-treated patients. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Tablets: Pale yellow, film coated, capsule-shaped tablets engraved with “P12” on one side.
Safety and efficacy for the treatment of bipolar mania have not been established in patients younger than 10 years; safety and effectiveness in patients with bipolar depression or for the maintenance treatment of bipolar disorder has not been established in patients less than 18 years. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Adverse events that were potentially dose-related with higher frequency in the 800 mg group compared to the 400 mg group included dizziness 8% vs. 15% dry mouth 4% vs. 10% and tachycardia 6% vs. 11%.
At steady-state the pharmacokinetics of the parent compound, in children and adolescents 10-17 years of age were similar to adults. However, when adjusted for dose and weight, AUC and C max of the parent compound were 41% and 39% lower, respectively, in children and adolescents than in adults. For the active metabolite, norquetiapine, AUC and C max were 45% and 31% higher, respectively, in children and adolescents than in adults. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. It is 83% bound to plasma proteins. Quetiapine Fumarate Extended-Release Tablets are indicated for the treatment of schizophrenia. The efficacy of Quetiapine Fumarate Extended-Release Tablets in schizophrenia was established in one 6-week and one maintenance trial in adults with schizophrenia. The following adverse reactions were identified during post approval use of Quetiapine Fumarate Immediate-Release Tablets. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Quetiapine Fumarate Immediate-Release Tablets or placebo as adjunct treatment to lithium or divalproex. Patients may or may not have received an adequate treatment course of lithium or divalproex prior to randomization. Quetiapine Fumarate Immediate-Release Tablets were superior to placebo when added to lithium or divalproex alone in the reduction of YMRS total score. Mahmoud RA. Dear health care professional letter regarding class labeling for atypical antipsychotics and risk of hyperglycemia and diabetes. Titusville, NJ: Janssen Pharmaceutica, Inc; 2004. From the FDA website. The effectiveness of Quetiapine Fumarate Extended-Release Tablets for the treatment of bipolar depression in patients under the age of 18 years has not been established. One 8-week trial was conducted to evaluate the safety and efficacy of Quetiapine Fumarate Extended-Release Tablets in the treatment of bipolar depression in pediatric patients 10 to 17 years of age. Yellow No. 5 tartrazine which may cause allergic-type reactions including bronchial asthma in certain susceptible persons. CBC monitored frequently during the first few months of therapy and should discontinue Quetiapine Fumarate Extended-Release Tablets at the first sign of a decline in WBC in absence of other causative factors. Your healthcare provider should check blood pressure in children and adolescents before starting quetiapine tablets and during therapy. Antidepressants may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. There was no increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24 and there was a reduction in risk with antidepressant use in patients aged 65 and older. You will likely gain more knowledge about what you are experiencing and build healthy ways to cope with symptoms when they arise or become triggered. Etminan M, Streiner DL, Rochon PA. Exploring the association between atypical neuroleptic agents and diabetes mellitus in older adults. Pharmacotherapy. Optimum duration of therapy currently not known, but efficacy of maintenance therapy with antipsychotics is well established.
This drug may also cause significant gain and a rise in your or levels. Quetiapine Fumarate Extended-Release Tablets in the bipolar mania trial. Quetiapine fumarate is a white to off-white crystalline powder which is moderately soluble in water. This drug may impair judgment, thinking, or motor skills; have patients avoid driving or operating machinery until adverse effects are determined. Advise patient and family to be alert for the emergence of agitation, irritability, and unusual changes in behavior, as well as the emergence of suicidality, and to report such symptoms immediately to the health care provider. What should I do if I have overdosed on this medication? How should I take Quetiapine Fumarate Extended-Release Tablets? Atalay A, Turhan N, Aki OE "A challenging case of syndrome of inappropriate secretion of antidiuretic hormone in an elderly patient secondary to quetiapine. Drug-related effects included decreases in matings and in matings resulting in pregnancy, and an increase in the interval to mate. Weight gain 23%; hyperglycemia, increased appetite 12%; decreased appetite 2%; hyponatremia, peripheral edema, SIADH postmarketing. At first, 50 milligrams mg 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 800 mg per day. The need for continuing existing EPS medication should be re-evaluated periodically. Somnolence combines the adverse reaction terms somnolence and sedation. feldene
Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Food and Drug Administration. Quetiapine Fumarate Extended-Release Tablets compared to 2% for placebo. Read the Guide and, if available, the Patient Information Leaflet provided by your before you start using and each time you get a refill. If you have any questions, ask your doctor or pharmacist. These results were not adjusted for normal growth. Lens changes have also been observed in adults, children, and adolescents during long-term quetiapine treatment but a causal relationship to quetiapine use has not been established. Nevertheless, the possibility of lenticular changes cannot be excluded at this time. Therefore, examination of the lens by methods adequate to detect cataract formation, such as slit lamp exam or other appropriately sensitive methods, is recommended at initiation of treatment or shortly thereafter, and at 6-month intervals during chronic treatment. Many drugs can interact with quetiapine. Not all possible interactions are listed here. At first, 50 milligrams mg once a day in the evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 300 mg per day. condyline price germany condyline
Adults: In placebo-controlled clinical trials with quetiapine, utilizing doses up to 800 mg per day, the incidence of any adverse reactions related to EPS ranged from 8% to 11% for quetiapine and 4% to 11% for placebo. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. In vitro enzyme inhibition data suggest that quetiapine and 9 of its metabolites would have little inhibitory effect on in vivo metabolism mediated by cytochromes CYP 1A2, 2C9, 2C19, 2D6 and 3A4. Quetiapine Fumarate Immediate-Release Tablets was greater than the incidence in placebo-treated patients. Increases in weight have been observed. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. When adjusted for weight, the AUC and C max of quetiapine were 41% and 39% lower, respectively, in children and adolescents compared to adults. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Tandon R. Improvement without impairment: a review of clinical data for quetiapine in the treatment of schizophrenia. J Clin Psychopharmacol. 2003; 23: S15-20. Seroquel may slow your thinking, decrease your reaction time, and cause drowsiness; using alcohol may worsen these side effects. Do not drive or operate heavy machinery until you know how this medication affects you. Monitor all patients for the emergence of agitation, irritability, clinical worsening, and other unusual changes in behavior, as well as the emergence of suicidality, especially during the initial few months of therapy or at times of dose changes. Monitor patients for symptoms of hyperglycemia. Perform fasting glucose testing in patients who develop hyperglycemia during treatment. Ensure that patients with risk factors for diabetes undergo fasting blood glucose testing at the start of therapy and periodically thereafter. Monitor patients with established diagnosis of diabetes mellitus regularly for worsening of glucose control. Perform eye exam at initiation of therapy to detect cataract formation and at 6-mo intervals during long-term treatment. Monitor patients requiring antipsychotic drug treatment after recovery from NMS for recurrence of NMS if quetiapine therapy is reintroduced. Baseline and periodic follow-up lipid evaluations are recommended for patients on quetiapine. There are limited published data on the use of quetiapine for treatment of schizophrenia and other psychiatric disorders during pregnancy. In a prospective observational study, 21 women exposed to quetiapine and other psychoactive medications during pregnancy delivered infants with no major malformations. Among 42 other infants born to pregnant women who used quetiapine during pregnancy, there were no major malformations reported one study of 36 women, 6 case reports. Due to the limited number of exposed pregnancies, these postmarketing data do not reliably estimate the frequency or absence of adverse outcomes. Further adjustments can be made in increments of 25 to 50 mg twice a day, in intervals of not less than 2 days. pharmacy spiriva reviews
Do not drive, operate machinery, or do other dangerous activities until you know how quetiapine tablets affects you. Quetiapine tablets may make you drowsy. In general, there was no indication of any different tolerability of quetiapine in the elderly compared to younger adults. Nevertheless, the presence of factors that might decrease pharmacokinetic clearance, increase the pharmacodynamic response to quetiapine, or cause poorer tolerance or orthostasis, should lead to consideration of a lower starting dose, slower titration, and careful monitoring during the initial dosing period in the elderly. Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke. Patients should be advised of the risk of somnolence or sedation which may lead to falls especially during the period of initial dose titration. Patients should be cautioned about performing any activity requiring mental alertness, such as operating a motor vehicle including automobiles or operating machinery, until they are reasonably certain quetiapine therapy does not affect them adversely. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Greenspan A, Gharabawi G, Kwentus J "Thyroid dysfunction during treatment with atypical antipsychotics. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Lee A, Giesbrecht E, Dunn E et al. Excretion of quetiapine in breast milk. Am J Psychiatry. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. Gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered. The possibility of obtundation, seizure or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. If antiarrhythmic therapy is administered, disopyramide, procainamide and quinidine carry a theoretical hazard of additive QT-prolonging effects when administered in patients with acute overdosage of quetiapine. Similarly it is reasonable to expect that the alpha-adrenergic-blocking properties of bretylium might be additive to those of quetiapine, resulting in problematic hypotension. What is the most important information I should know about quetiapine tablets? The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive-compulsive disorder OCD or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. Acute withdrawal symptoms, such as insomnia, nausea, and vomiting have been described after abrupt cessation of atypical antipsychotic drugs, including quetiapine. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile. In some patients, a worsening of more than one of the metabolic parameters of weight, blood glucose, and lipids was observed in clinical studies. Changes in these metabolic profiles should be managed as clinically appropriate. The efficacy of Quetiapine Fumarate Immediate-Release Tablets in the treatment of acute manic episodes was also established in 3 placebo-controlled trials in patients who met DSM-IV criteria for bipolar I disorder with manic episodes. These trials included patients with or without psychotic features and excluded patients with rapid cycling and mixed episodes. Of these trials, 2 were monotherapy 12 weeks and 1 was adjunct therapy 3 weeks to either lithium or divalproex. Key outcomes in these trials were change from baseline in the YMRS score at 3 and 12 weeks for monotherapy and at 3 weeks for adjunct therapy. Adjunct therapy is defined as the simultaneous initiation or subsequent administration of Quetiapine Fumarate Immediate-Release Tablets with lithium or divalproex. There is no specific antidote to quetiapine. Therefore, appropriate supportive measures should be instituted. The possibility of multiple drug involvement should be considered. ufco.info vistaril
This is not a complete list of possible side effects. ER. Bioavailability is 100%. Food increases the immediate-release C max and AUC by 25% and 15%, respectively. High-fat meal increases the ER C max and AUC by as much as 52% and 22%, respectively; however, a light meal has no effect. Steady-state concentrations are expected within 2 days. Do not take Quetiapine Fumarate Extended-Release Tablets if you are allergic to quetiapine fumarate or any of the ingredients in Quetiapine Fumarate Extended-Release Tablets. See the end of this Medication Guide for a complete list of ingredients in Quetiapine Fumarate Extended-Release Tablets. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries. Esophageal dysmotility and aspiration have been associated with antipsychotic drug use. Aspiration pneumonia is a common cause of morbidity and mortality in elderly patients, in particular those with advanced Alzheimer's dementia. Quetiapine and other antipsychotic drugs should be used cautiously in patients at risk for aspiration pneumonia. Advise patient taking antihypertensives to monitor BP at regular intervals. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment. Asymptomatic, transient, and reversible elevations in serum transaminases mainly ALT may occur. The dose of quetiapine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of quetiapine. Sernyak MJ, Gulanski B, Rosenheck R "Undiagnosed hyperglycemia in patients treated with atypical antipsychotics. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Quetiapine Fumarate Extended-Release Tablets for a condition for which it was not prescribed. Do not give Quetiapine Fumarate Extended-Release Tablets to other people, even if they have the same symptoms you have. It may harm them.
Anon. Academic highlights: Seroquel: a putative atypical antipsychotic drug with serotonin- and dopamine-receptor antagonist properties: preclinical and early clinical trials in schizophrenia. J Clin Psychiatry. Has antipsychotic effects, apparently caused by dopamine- and serotonin-receptor blockade in the CNS. What are the risk factors and causes of depression? Adverse Reactions Associated with Discontinuation of Treatment in Short-Term, Placebo-Controlled Trials. US Food and Drug Administration. FDA drug safety communication: Antipsychotic drug labels updated in use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns. price innopran wiki
Somnolence combines adverse reaction terms somnolence and sedation. Safety and efficacy of ER not established; not approved for use in children. Safety and efficacy of immediate-release has been established in the treatment of bipolar mania in children 10 to 17 yr of age and in the treatment of schizophrenia in children 13 to 17 yr of age. May decrease the effects of quetiapine; increased doses of quetiapine may be necessary to maintain control of psychotic symptoms. Quetiapine may increase the plasma concentrations of the active metabolite of carbamazepine, resulting in neurotoxicity. If neurotoxicity occurs, it may be necessary to discontinue one or both drugs. Patients who require chronic therapy should be maintained on the smallest dose that produces a satisfactory response. Quetiapine may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision especially during the first week of use which may lead to falls, fractures or other injuries. Make sure you know how you react to quetiapine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well. Possible additive CNS depressant effects; use with caution. Avoid alcohol. How can I take Seroquel safely? Read this Medication Guide before you start taking Quetiapine Fumarate Extended-Release Tablets and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Sussman N. The implications of weight changes with antipsychotic treatment. J Clin Psychopharmacol. Quetiapine Fumarate Immediate-Release Tablets 600 mg compared to 0% of patients receiving placebo. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers. Such monitoring should include daily observation by families and caregivers. Prescriptions for Quetiapine Fumarate Extended-Release Tablets should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. WBC followed until recovery. SD: standard deviation; SE: standard error; LS Mean: least-squares mean; CI: unadjusted confidence interval. Coadministration may increase the mean C max of quetiapine. Monitor the response of the patient when starting, stopping, or changing the valproic acid dose. Be prepared to change the quetiapine dose as needed. In addition, the risk of leukopenia or neutropenia may be increased. If leukopenia or neutropenia occurs, stop one or both drugs. An increased risk of mortality, possibly due to heart failure or sudden death, has been reported with the use of atypical antipsychotic agents in the treatment of behavioral disorders in the elderly patient with dementia. buy celebrex store otc
Kuperberg GR. Advances in the treatment of schizophrenia. Br J Clin Pract. It is not known if quetiapine tablets are safe and effective in children under 10 years of age. Tell your doctor if you have ever had diabetes. Avoid contact sports or other situations where bruising or injury could occur. The recommended initial dose, titration, dose range and maximum Quetiapine Fumarate Extended-Release Tablets dose for each approved indication is displayed in Table 1 below. Given these considerations, Quetiapine Fumarate Extended-Release Tablets should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who appear to suffer from a chronic illness that 1 is known to respond to antipsychotic drugs, and 2 for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. Citrome LL, Jaffe AB. Relationship of atypical antipsychotics with development of diabetes mellitus. Ann Pharmacother. Quetiapine tablets are indicated for the maintenance treatment of bipolar I disorder, as an adjunct to lithium or divalproex. Efficacy was established in two maintenance trials in adults. Quetiapine Fumarate Extended-Release Tablets. These falls may cause serious injuries. There is no race effect on the pharmacokinetics of quetiapine. Do not keep outdated medicine or medicine no longer needed. Advise patient to avoid strenuous activity during periods of high temperature or humidity. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use quetiapine tablets for a condition for which it was not prescribed. Monitor for increases in weight and lipids. generic ranitidine order online europe
Compared with placebo, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for major depressive disorders and other psychiatric disorders. Appropriately monitor patients of all ages who are started on antidepressant therapy and observe them closely for clinical worsening, suicidality, or unusual changes in behavior. Advise families and caregivers of the need for close observation and communication with the prescriber. Quetiapine ER is not approved for use in children. Quetiapine immediate-release is not approved for use in children younger than 10 yr of age. Quetiapine Fumarate Immediate-Release Tablets 800 mg compared to 0% of patients receiving placebo. Quetiapine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down. Antagonism at receptors other than dopamine and serotonin with similar or greater affinities may explain some of the other effects of quetiapine and norquetiapine: antagonism at histamine H 1 receptors may explain the somnolence, antagonism at adrenergic α 1b receptors may explain the orthostatic hypotension, and antagonism at muscarinic M 1 receptors may explain the anticholinergic effects. In both studies, quetiapine was superior to placebo in increasing the time to recurrence of any mood event. The treatment effect was present for increasing time to recurrence of both manic and depressed episodes. The effect of quetiapine was independent of any specific subgroup assigned mood stabilizer, sex, age, race, most recent bipolar episode, or rapid cycling course. Day 3 for both dose groups. clomiphene
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The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Quetiapine caused a dose-related increase in pigment deposition in thyroid gland in rat toxicity studies which were 4 weeks in duration or longer and in a mouse 2-year carcinogenicity study. The information below is derived from a clinical trial database for Quetiapine Fumarate Immediate-Release Tablets consisting of over 1000 pediatric patients. Increased triglycerides 22%; increased cholesterol 18%; decreased HDL cholesterol 10%; increased LDL cholesterol 8%; elevations in GGT less than 5%; elevated serum creatine phosphokinase. price zithromax work
Take this medicine with a full glass of water. You may take quetiapine with or without food. Pfizer Inc. Geodon ziprasidone prescribing information. New York, NY; 2004 Aug. Do not give quetiapine to a child without a doctor's advice. Extended-release quetiapine Seroquel XR is for use only in adults and should not be given to anyone younger than 18 years old. Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking Quetiapine Fumarate Extended-Release Tablets. What is the general approach to treating depression?
This drug is not approved for use in patients with dementia-related psychosis. The most common adverse reactions reported in adults have included somnolence, dry mouth, dizziness, constipation, asthenia, abdominal pain, postural hypotension, pharyngitis, weight gain, lethargy, increased ALT, and dyspepsia. In children and adolescents, the most common adverse reactions reported have included somnolence, dizziness, fatigue, increased appetite, nausea, vomiting, dry mouth, tachycardia, and increased weight. Quetiapine is extensively metabolized by the liver. The major metabolic pathways are sulfoxidation to the sulfoxide metabolite and oxidation to the parent acid metabolite; both metabolites are pharmacologically inactive. In vitro studies using human liver microsomes revealed that the cytochrome P450 3A4 isoenzyme is involved in the metabolism of quetiapine to its major, but inactive, sulfoxide metabolite and in the metabolism of its active metabolite N-desalkyl quetiapine.
Consider lower starting dose, slower titration, and careful monitoring in debilitated patients and patients with predisposition to hypotensive reactions. Lamberti JS, Crilly JF, Maharaj K. Prevalence of diabetes mellitus among outpatients with severe mental disorders receiving atypical antipsychotic drugs. J Clin Psychiatry. The information contained in the Truven Health Micromedex products as delivered by Drugs.